OVERVIEW

• Two internal light sources
• Integrated white reference for outstanding long term stability
• 3/4" probe tip with different lengths
• GMP compliant design
• ATEX zone 20/21 certified

Applications

	Continuous Manufacturing PAT-Applications in continuous pharmaceutical manufacturing processes
	High Shear Wet Granulation Introduction to the Application of NIR based PAT to monitor High Shear Wet Granulation
	Tablet press feed frame Potency & Blend/Granule Uniformity measurement with NIR probe in the feed frame of tablet presses
	Fluid bed coating Online NIR spectroscopy tablet and granule coating thickness measurement
	Roller compaction NIR can be used to measure ribbon density and porosity
	Hot melt extrusion NIR based inline monitoring for pharmaceutical hot melt extrusion

More Information

SentroProbe DR LS NIR is a probe for measurement of diffuse reflectance in the NIR range. The probe contains two redundant working tungsten bulbs which illuminate the sample directly. Due to this direct illumination the highest possible signal-to-noise ratio will be achieved. Each bulb has a nominal lifetime of 14,000hrs.

 

There are multiple options for mounting the SentroProbe DR LS to the processing equiment. Most commonly a 2" flange is used together with a hygienic clamp. This flange can be welded to a position defined by the user. Also avalailable is a flexible flange that provides maximum of flexibility for installations of the probe.

 

 

 

 

 

 

Part of the internal optics is a PTFE based standard integrated at the probe tip. This internal standard can be used for automated drift correction or as reference. The use of one of this options provides a superior long term stability without the need of external referencing.
The reflected light is detected by a 400µm single core fiber. The connection between probe and spectrometer based on such a single core fiber is very cost efficient.

The probe tip is made of stainless steel which is electro polished and a Sapphire window. It is designed for a measurement in direct contact with the sample. The diameter of the measurement spot is approxiametly 5mm. Optionally the probe tip can be heated. This option ensures a clean window for measurements of sticking product (e.g. wet granulation).

 

There are no maintenance needs for the probe except the replacement of the bulbs. This replacement requires no special tools and can be done by trained service engineers.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Technical Data

 

Parameter	Specification
Technology	Diffuse reflectance
Light source	2 redundant tungsten light sources
Nominal life time	14,000hrs for each bulb
Lamp power	Configurable up to 5W
Wavelength range	400 - 2500nm
Measurement spot	approximately 5mm
Detection fiber	Single core 400µm fiber optical cable
Measurement distance	Direct product contact
Probe tip diameter	3/4" (19mm)
Standard lengths probe tip	65mm, 100mm, 200mm, 300mm
Ambient conditions	0°C - 60°C, 0-10bar
Installation	Flexible and welded 2" hygienic flanges
Rating	IP65, ATEX zone 20/21, GMP compliant
Optional features	Configurable probe tip heating